Current state of laser synthesis of metal and alloy nanoparticles as ligand-free reference materials for nano-toxicological assays

• Christoph Rehbock,
• Jurij Jakobi,
• Lisa Gamrad,
• Selina van der Meer,
• Daniela Tiedemann,
• Ulrike Taylor,
• Wilfried Kues,
• Detlef Rath and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2014, 5, 1523–1541, doi:10.3762/bjnano.5.165

• , mammalian cells and bacteria are considered. Keywords: albumin; gold-silver; implant alloy; laser ablation; nickel-titanium; size control; wear debris; Introduction The widespread use of medical implants consisting of metals (e.g., gold coatings [1]) and alloys (e.g., NiTi, CoCr, stainless steel) [2][3][4

• for binary and ternary implant alloy nanoparticles are reviewed. The control of particle compositions is demonstrated with totally homogeneous AuAg alloy reference nanoparticle and examples are given as to how their composition is linked to nanotoxicologial effects. Review Size control of laser

• and allows utilization of highly concentrated colloidal nanoparticle reference materials. Laser-fabricated binary and ternary implant alloy nanoparticles In the previous chapters size control and stability of relatively inert reference materials were reviewed. However, for toxicity assays